Compound class:
Synthetic organic
Comment: SRTCX1003 activates sirtuin 1 (SIRT1), an NAD+-dependent protein deacetylase [1].
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Bioactivity Comments |
In vitro, SRTCX1003 inhibits TNFα stimulated transcriptional activation of NF-κB, and in an in vivo mouse model, inhibits LPS-induced TNFα secretion. The IC50 values for these actions are 950nM and 12520nM respectively [1]. |