compound 4d [PMID: 21851057]

Ligand id: 7516

Name: compound 4d [PMID: 21851057]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 55.49
Molecular weight 261.14
XLogP 2.95
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
bromodomain containing 2 Hs Inhibitor Inhibition 5.8 pIC50 - 1
pIC50 5.8 (IC50 1.6x10-6 M) [1]
Description: Inhibition of binding to recombinant BRD2-BD1.
bromodomain containing 4 Hs Inhibitor Inhibition 5.3 pIC50 - 1
pIC50 5.3 (IC50 4.8x10-6 M) [1]
Description: Inhibition of binding to recombinant BRD4-BD1.