Synonyms: compound 1 [PMID: 24747528] | TPT-260 | TPT260
Compound class:
Synthetic organic
Comment: R55 is an experimental compound with potential therapeutic implications for Alzheimer's disease [1].
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Bioactivity Comments |
In vitro R55 stabilizes retromer by 10oC. This activity increases retromer levels in neuronal cultures and reduces APP levels in endosomes. APP is shifted away from BACE1-dependent processing, towards a neuroprotective pathway [1]. There is no classical binding affinity data available for this ligand, quantifying the interaction of R55 with any single molecular target, so we have not tagged a primary molecular target in this instance. |