CCL14   Click here for help

GtoPdb Ligand ID: 753

Synonyms: CCL14a | CKβ1 | haemofiltrate CC chemokine 1 (HCC-1) | HCC-1(1-74)
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: The ligand is cleaved from the precursor C-C motif chemokine 14 (represents residues 20-93)
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Natural/Endogenous Targets
Target
CCR1
CCR5
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CCR1 Ligand is endogenous in the given species Hs Agonist Full agonist 7.4 pKi - 1
⤷ pKi 7.4 [1]
CCR5 Ligand is endogenous in the given species Hs Agonist Full agonist 7.2 pKi - 2
⤷ pKi 7.2 [2]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Endogenous ligands at ACKR1 CXCL5 (CXCL5, P42830), CXCL6 (CXCL6, P80162), CXCL8 (CXCL8, P10145), CXCL11 (CXCL11, O14625), CCL2 (CCL2, P13500), CCL5 (CCL5, P13501), CCL7 (CCL7, P80098), CCL11 (CCL11, P51671), CCL14 (CCL14, Q16627), CCL17 (CCL17, Q92583)
Endogenous agonists at ACKR2 CCL2 (CCL2, P13500), CCL3 (CCL3, P10147), CCL4 (CCL4, P13236), CCL5 (CCL5, P13501), CCL7 (CCL7, P80098), CCL8 (CCL8, P80075), CCL11 (CCL11, P51671), CCL13 (CCL13, Q99616), CCL14 (CCL14, Q16627), CCL17 (CCL17, Q92583), CCL22 (CCL22, O00626)