huwentoxin IV   Click here for help

GtoPdb Ligand ID: 7570

Synonyms: huwentoxin-4 | HwTx-IV
Comment: Toxin from Haplopelma schmidti (Chinese bird spider).
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Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Nav1.2 Hs Gating inhibitor Voltage-dependent inhibition 7.8 pKd - 1
pKd 7.8 [1]
Description: Automated patch clamp (QPatch) of transfected human embryonic kidney cells (HEK293)
Conditions: Holding potential = -65 mV, the potential for half-maximal inactivation of the sodium current