AZD1332

Ligand id: 7700

Name: AZD1332

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 100.64
Molecular weight 391.13
XLogP 3.56
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Pending publication of data, the values for AZD1332 are derived from the compound's record in AstaZeneca's Open Innovation Pharmacology Toolbox.
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
neurotrophic receptor tyrosine kinase 1 Inhibitor Inhibition >8.3 pIC50 - 1
pIC50 >8.3 (IC50 <5x10-9 M) [1]
Description: NIH3T3 cells over expressing TrkA
neurotrophic receptor tyrosine kinase 2 Inhibitor Inhibition >8.3 pIC50 - 1
pIC50 >8.3 (IC50 <5x10-9 M) [1]
Description: NIH3T3 cells over expressing TrkB
neurotrophic receptor tyrosine kinase 3 Inhibitor Inhibition >8.3 pIC50 - 1
pIC50 >8.3 (IC50 <5x10-9 M) [1]
Description: NIH3T3 cells over expressing TrkC