AZD1775

Ligand id: 7702

Name: AZD1775

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 100.96
Molecular weight 500.26
XLogP 2.93
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Pending publication the data presented here is derived from the compound's record in AstaZeneca's Open Innovation Pharmacology Toolbox.
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
WEE1 G2 checkpoint kinase Inhibitor Inhibition 8.3 pIC50 - 1
pIC50 8.3 (IC50 5.18x10-9 M) [1]