AZD3463

Ligand id: 7706

Name: AZD3463

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 92.09
Molecular weight 448.18
XLogP 3.68
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Pending publication, the data presented here is derived from the compound's record in AstaZeneca's Open Innovation Pharmacology Toolbox
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Insulin-like growth factor I receptor Inhibitor Inhibition >8.0 pIC50 - 1
pIC50 >8.0 (IC50 <1x10-8 M) [1]
ALK receptor tyrosine kinase Inhibitor Inhibition >8.0 pIC50 - 1
pIC50 >8.0 (IC50 <1x10-8 M) [1]