AZD4547

Ligand id: 7707

Name: AZD4547

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 9
Topological polar surface area 91.51
Molecular weight 463.26
XLogP 4.58
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Pending publication, the data presented here is derived from the compound's record in AstaZeneca's Open Innovation Pharmacology Toolbox
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
fibroblast growth factor receptor 1 Inhibitor Inhibition >8.3 – 9.1 pIC50 - 1-2
pIC50 >8.3 – 9.1 (IC50 <5x10-9 – 7x10-10 M) [1-2]
fibroblast growth factor receptor 2 Inhibitor Inhibition >8.3 pIC50 - 1
pIC50 >8.3 (IC50 <5x10-9 M) [1]
fibroblast growth factor receptor 3 Inhibitor Inhibition >8.3 pIC50 - 1
pIC50 >8.3 (IC50 <5x10-9 M) [1]
kinase insert domain receptor Inhibitor Inhibition 7.6 pIC50 - 1
pIC50 7.6 (IC50 2.4x10-8 M) [1]
fibroblast growth factor receptor 4 Inhibitor Inhibition 6.8 pIC50 - 1
pIC50 6.8 (IC50 1.65x10-7 M) [1]
Insulin-like growth factor I receptor Inhibitor Inhibition 6.2 pIC50 - 1
pIC50 6.2 (IC50 5.81x10-7 M) [1]