AZD7325

Ligand id: 7712

Name: AZD7325

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 90.13
Molecular weight 354.15
XLogP 3.64
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
AZD7325 displaces [3H]flunitrazepam from the benzodiazepine binding site of GABAA channels composed of α2β3γ2 subunits, expressed in Sf9 cells [1].
Some of the data presented for this ligand is derived from the compound's record in AstaZeneca's Open Innovation Pharmacology Toolbox, pending publication.
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
MT1 receptor Antagonist Antagonist 6.9 pIC50 - 2
pIC50 6.9 (IC50 1.26x10-7 M) [2]
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
GABAA receptor α2 subunit Allosteric modulator Positive 9.5 pKi - 2
pKi 9.5 (Ki 3x10-10 M) [2]
GABAA receptor α3 subunit Allosteric modulator Positive 8.9 pKi - 2
pKi 8.9 (Ki 1.3x10-9 M) [2]