AZD8542

Ligand id: 7716

Name: AZD8542

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 69.04
Molecular weight 412.19
XLogP 5.09
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Pending publication, the data presented here is derived from the compound's record in AstaZeneca's Open Innovation Pharmacology Toolbox
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
SMO Antagonist Antagonist 8.5 pIC50 - 1
pIC50 8.5 (IC50 3x10-9 M) [1]
Selectivity at mouse GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
SMO Antagonist Antagonist 8.8 pIC50 - 1
pIC50 8.8 (IC50 1.5x10-9 M) [1]