BGJ-398

Ligand id: 7877

Name: BGJ-398

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 95.09
Molecular weight 559.19
XLogP 3.49
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
fibroblast growth factor receptor 1 Inhibitor Inhibition 9.1 pIC50 - 1
pIC50 9.1 (IC50 9x10-10 M) [1]
fibroblast growth factor receptor 3 Inhibitor Inhibition 9.0 pIC50 - 1
pIC50 9.0 (IC50 1x10-9 M) [1]
fibroblast growth factor receptor 2 Inhibitor Inhibition 8.9 pIC50 - 1
pIC50 8.9 (IC50 1.4x10-9 M) [1]
fibroblast growth factor receptor 4 Inhibitor Inhibition 7.2 pIC50 - 1
pIC50 7.2 (IC50 6x10-8 M) [1]
kinase insert domain receptor Inhibitor Inhibition 6.7 pIC50 - 1
pIC50 6.7 (IC50 1.8x10-7 M) [1]