CEP-32496

Ligand id: 7880

Name: CEP-32496

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 120.63
Molecular weight 517.16
XLogP 5.43
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
In vitro, CEP-32496 inhibits BRAFV600E-induced MEK phosphorylation with an IC50 of 82nM [1]. Additional targets for CEP-32496 include c-KIT, LCK, PDGRFβ, RET and Abl kinases, with Kd values of 2-3nM [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
B-Raf proto-oncogene, serine/threonine kinase Inhibitor Inhibition 7.4 pKd - 1
pKd 7.4 (Kd 3.6x10-8 M) [1]
Description: Inhibition of wild type BRAF activity.
Raf-1 proto-oncogene, serine/threonine kinase Inhibitor Inhibition 7.4 pKd - 1
pKd 7.4 (Kd 3.9x10-8 M) [1]