BMS-777607

Ligand id: 7953

Name: BMS-777607

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 106.78
Molecular weight 512.11
XLogP 4.63
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
AXL receptor tyrosine kinase Inhibitor Inhibition 9.0 pIC50 - 1
pIC50 9.0 (IC50 1.1x10-9 M) [1]
macrophage stimulating 1 receptor Inhibitor Inhibition 8.7 pIC50 - 1
pIC50 8.7 (IC50 1.8x10-9 M) [1]
MET proto-oncogene, receptor tyrosine kinase Inhibitor Inhibition 8.4 pIC50 - 1
pIC50 8.4 (IC50 3.9x10-9 M) [1]
TYRO3 protein tyrosine kinase Inhibitor Inhibition 8.4 pIC50 - 1
pIC50 8.4 (IC50 4.3x10-9 M) [1]
MER proto-oncogene, tyrosine kinase Inhibitor Inhibition 7.8 pIC50 - 1
pIC50 7.8 (IC50 1.4x10-8 M) [1]