AKN-028

Ligand id: 7969

Name: AKN-028

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 92.51
Molecular weight 302.13
XLogP 2.06
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
AKN-028 shows cytotoxic activity in several acute myeloid leukemia (AML) cell lines [1].
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
fms related tyrosine kinase 3 Inhibitor Inhibition 8.2 pIC50 - 1
pIC50 8.2 (IC50 6x10-9 M) [1]
KIT proto-oncogene receptor tyrosine kinase Inhibitor Inhibition 7.5 pIC50 - 1
pIC50 7.5 (IC50 2.9x10-8 M) [1]
Description: Inhibition of KIT autophosphorylation in human AML M07 cells which overexpress KIT