rilotumumab   Click here for help

GtoPdb Ligand ID: 7986

Synonyms: AMG 102 | AMG102
Compound class: Antibody
Comment: Rilotumumab is a monoclonal antibody directed against hepatocyte growth factor (HGF), developed as a treatment for solid tumours.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. Peptide sequence BLAST search using the heavy and light chain variable regions of rilotumumab provides 100% matches to sequences covered by patent US8609090 [1], and to the antibody with designation 2.12.1.
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
hepatocyte growth factor Primary target of this compound Hs Antibody Binding 9.7 – 10.3 pKd - 1
⤷ pKd 9.7 – 10.3 (Kd 2.2x10-10 – 5.4x10-11 M) [1]
Description: Dissociation equilibrium constant calculated using two different assay methods (kinetic vs. equilibrium/solution)