CHIR-98014

Ligand id: 8016

Name: CHIR-98014

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 149.71
Molecular weight 485.09
XLogP 3.8
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
glycogen synthase kinase 3 beta Hs Inhibitor Inhibition 9.2 pIC50 - 5
pIC50 9.2 (IC50 5.8x10-10 M) [5]
glycogen synthase kinase 3 alpha Hs Inhibitor Inhibition 9.2 pIC50 - 5
pIC50 9.2 (IC50 6.5x10-10 M) [5]