AMG-900

Ligand id: 8060

Name: AMG-900

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 139.97
Molecular weight 503.15
XLogP 6.84
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Surface plasmon resonance analysis has shown that 3 pan-Aurora kinase inhibitors (danusertib, tozasertib and AMG-900) all have greater target residence time (τ) on Aurora B compared to Aurora A. Of these three inhibitors, AMG-900 has the longest target residence time on Aurora B with τ of 12 hours [2].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
aurora kinase C Inhibitor Inhibition 9.0 pIC50 - 1
pIC50 9.0 (IC50 1x10-9 M) [1]
aurora kinase B Inhibitor Inhibition 8.4 pIC50 - 1
pIC50 8.4 (IC50 4x10-9 M) [1]
aurora kinase A Inhibitor Inhibition 8.3 pIC50 - 1
pIC50 8.3 (IC50 5x10-9 M) [1]