CFI-400945

Ligand id: 8063

Name: CFI-400945

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 79.48
Molecular weight 534.26
XLogP 6.64
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
CFI-400945 significantly inhibits tumour growth in in vivo xenograft models [1].
Known off-targets include ABLT315I, TRKA, TRKB and BMX.
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
polo like kinase 4 Inhibitor Inhibition 8.6 pIC50 - 1
pIC50 8.6 (IC50 2.8x10-9 M) [1]