BIX02188

Ligand id: 8064

Name: BIX02188

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 87.46
Molecular weight 412.19
XLogP 4.91
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
ERK5 is a known off-target of this compound. but it does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2 [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
mitogen-activated protein kinase kinase 5 Inhibitor Inhibition 8.4 pIC50 - 1
pIC50 8.4 (IC50 4.3x10-9 M) [1]
mitogen-activated protein kinase 7 Inhibitor Inhibition 6.1 pIC50 - 1
pIC50 6.1 (IC50 8.1x10-7 M) [1]