compound 12 [PMID: 22521646]

Ligand id: 8125

Name: compound 12 [PMID: 22521646]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 59.29
Molecular weight 364.17
XLogP 4.41
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
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Target Type Action Affinity Units Concentration range (M) Reference
mitogen-activated protein kinase 14 Inhibitor Inhibition 9.2 pIC50 - 1
pIC50 9.2 (IC50 6.4x10-10 M) [1]