compound 10 [PMID: 23147077]

Ligand id: 8133

Name: compound 10 [PMID: 23147077]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 64.22
Molecular weight 359.17
XLogP 5.73
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Note that some bioactivity data may be attributable to the hydrochloride salt of compound 10 (CHEMBL2205637).
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
mitogen-activated protein kinase kinase kinase 5 Inhibitor Inhibition 8.0 pIC50 - 1
pIC50 8.0 (IC50 1x10-8 M) [1]
mitogen-activated protein kinase kinase kinase 6 Inhibitor Inhibition 6.3 pIC50 - 1
pIC50 6.3 (IC50 5.1x10-7 M) [1]