compound 27 [PMID: 19854648]

Ligand id: 8168

Name: compound 27 [PMID: 19854648]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 76.24
Molecular weight 403.05
XLogP 3.23
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
eukaryotic translation initiation factor 2 alpha kinase 1 Inhibitor Inhibition 8.2 pIC50 - 1
pIC50 8.2 (IC50 6.31x10-9 M) [1]