compound 16 [PMID: 17480064]

Ligand id: 8177

Name: compound 16 [PMID: 17480064]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 2
Topological polar surface area 70.67
Molecular weight 340.13
XLogP 3.61
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
mitogen-activated protein kinase-activated protein kinase 2 Inhibitor Inhibition 8.1 pIC50 - 1
pIC50 8.1 (IC50 8.5x10-9 M) [1]
mitogen-activated protein kinase-activated protein kinase 3 Inhibitor Inhibition 6.7 pIC50 - 1
pIC50 6.7 (IC50 2.1x10-7 M) [1]
mitogen-activated protein kinase-activated protein kinase 5 Inhibitor Inhibition 6.1 pIC50 - 1
pIC50 6.1 (IC50 8.1x10-7 M) [1]