compound 19a [PMID: 21855335]

Ligand id: 8186

Name: compound 19a [PMID: 21855335]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 103.24
Molecular weight 490.2
XLogP 2.89
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Compound 19a is highly selective for PTK6 compared to Aurora kinase B and the Src family tyrosine kinase, Lck [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
protein tyrosine kinase 6 Inhibitor Inhibition 8.7 pIC50 - 1
pIC50 8.7 (IC50 2x10-9 M) [1]
LCK proto-oncogene, Src family tyrosine kinase Inhibitor Inhibition 6.7 pIC50 - 1
pIC50 6.7 (IC50 1.8x10-7 M) [1]