compound 15b [PMID: 16539403]

Ligand id: 8194

Name: compound 15b [PMID: 16539403]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 68.76
Molecular weight 359.17
XLogP 2.86
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Compound 15b is minimally selective for TGFβR1 compared to TGFβR2 and MLK7 (aka ZAK sterile alpha motif and leucine zipper containing kinase AZK, or ZAK) [1].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
ZAK sterile alpha motif and leucine zipper containing kinase AZK Hs Inhibitor Inhibition 6.2 pIC50 - 1
pIC50 6.2 (IC50 7.08x10-7 M) [1]
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
transforming growth factor beta receptor 1 Hs Inhibitor Inhibition 7.1 pIC50 - 1
pIC50 7.1 (IC50 7.9x10-8 M) [1]
transforming growth factor beta receptor 2 Hs Inhibitor Inhibition 6.4 pIC50 - 1
pIC50 6.4 (IC50 3.52x10-7 M) [1]