compound R-16 [PMID: 21967808]

Ligand id: 8213

Name: compound R-16 [PMID: 21967808]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 5
Rotatable bonds 9
Topological polar surface area 140.38
Molecular weight 594.23
XLogP 4.91
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
In a selectivity profile screen compound R-16 inhibited 68/353 kinases tested by >90% [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
interleukin 1 receptor associated kinase 3 Inhibitor Inhibition - - - 1
[1]
Description: Measured as % inhibition using 1μM compound.
unc-51 like autophagy activating kinase 1 Inhibitor Inhibition - - - 1
[1]
Description: Measured as % inhibition using 1μM compound.
sugen kinase 110 Inhibitor Inhibition - - - 1
[1]
Description: Measured as % inhibition using 1μM compound.
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
MET proto-oncogene, receptor tyrosine kinase Inhibitor Inhibition 7.6 pIC50 - 1
pIC50 7.6 (IC50 2.4x10-8 M) [1]
tyrosine kinase with immunoglobulin like and EGF like domains 1 Inhibitor Inhibition - - - 1
[1]
Description: Measured as % inhibition using 1μM compound.