compound 1 [PMID: 24793884]

Ligand id: 8218

Name: compound 1 [PMID: 24793884]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 100.55
Molecular weight 250.04
XLogP 1.62
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
cell division cycle 7 Inhibitor Inhibition 6.5 pIC50 - 1
pIC50 6.5 (IC50 3.23x10-7 M) [1]
cyclin dependent kinase 8 Inhibitor Inhibition - - - 1
[1]
Description: Measured as % inhibition using 1μM compound.
mitogen-activated protein kinase kinase kinase 19 Inhibitor Inhibition - - - 1
[1]
Description: Measured as % inhibition using 1μM compound.
TAO kinase 3 Inhibitor Inhibition - - - 1
[1]
Description: Measured as % inhibition using 1μM compound.