compound 74 [PMID: 24793884]

Ligand id: 8219

Name: compound 74 [PMID: 24793884]

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 136.02
Molecular weight 364.99
XLogP 1.65
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
OXSR1 activity is inhibited by approximately 86% (average of n=2) in the presence of 1μM compound 74 [PMID: 24793884] [1] (note that OXSR1 is referred to as OSR1 in the article's Supplementary data table).
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
cell division cycle 7 Inhibitor Inhibition 8.4 pIC50 - 1
pIC50 8.4 (IC50 3.77x10-9 M) [1]
serine/threonine kinase 32B Inhibitor Inhibition - - - 1
[1]
Description: Measured as % inhibition using 1μM compound.
oxidative stress responsive 1 Inhibitor Inhibition - - - 1
[1]
Description: Measured as % inhibition using 1μM compound.