A-366

Ligand id: 8238

Name: A-366

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 60.08
Molecular weight 329.21
XLogP 2.08
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
A-366 is >100-fold selective for EHMT1/2 compared to other methyltransferases [2].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
euchromatic histone lysine methyltransferase 1 Inhibitor Inhibition 8.5 pIC50 - 1-2
pIC50 8.5 (IC50 3.8x10-8 M) [1-2]
euchromatic histone lysine methyltransferase 2 Inhibitor Inhibition 8.5 pIC50 - 1-2
pIC50 8.5 (IC50 3.3x10-9 M) [1-2]