chlorpromazine

Ligand id: 83

Name: chlorpromazine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 31.78
Molecular weight 318.1
XLogP 4.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
H1 receptor Antagonist Antagonist 8.2 pKi - 7
pKi 8.2 [7]
5-HT2A receptor Antagonist Inverse agonist 8.1 pKi - 7
pKi 8.1 [7]
5-HT2C receptor Antagonist Antagonist 7.6 – 8.2 pKi - 5,7
pKi 7.6 – 8.2 [5,7]
D4 receptor Antagonist Antagonist 7.8 pKi - 8
pKi 7.8 [8]
5-HT6 receptor Antagonist Inverse agonist 7.7 – 7.8 pKi - 6,11
pKi 7.7 – 7.8 [6,11]
α2B-adrenoceptor Antagonist Antagonist 7.2 – 8.3 pKi - 1-2
pKi 7.2 – 8.3 [1-2]
5-HT7 receptor Antagonist Inverse agonist 7.6 pKi - 11
pKi 7.6 [11]
D3 receptor Antagonist Antagonist 7.2 – 7.5 pKi - 4,13
pKi 7.2 – 7.5 [4,13]
D2 receptor Antagonist Antagonist 7.0 – 7.6 pKi - 4,13
pKi 7.0 – 7.6 [4,13]
α2C-adrenoceptor Antagonist Antagonist 6.9 – 7.4 pKi - 1-2
pKi 6.9 – 7.4 [1-2]
D1 receptor Antagonist Antagonist 7.1 pKi - 15
pKi 7.1 [15]
D5 receptor Antagonist Antagonist 6.9 pKi - 15
pKi 6.9 [15]
α2A-adrenoceptor Antagonist Antagonist 5.9 – 6.6 pKi - 1-2
pKi 5.9 – 6.6 [1-2]
5-HT1A receptor Antagonist Antagonist 6.2 pKi - 9
pKi 6.2 [9]
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPC5 Channel blocker - - - -
Maxi Cl- Activator (extracellular chlorpromazine) - - - -
Selectivity at mouse GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
5-HT7 receptor Antagonist Inverse agonist 5.3 pKi - 10
pKi 5.3 [10]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
5-HT2A receptor Antagonist Inverse agonist 8.7 pKi - 3
pKi 8.7 [3]
5-HT6 receptor Antagonist Inverse agonist 8.4 pKi - 12
pKi 8.4 [12]
5-HT7 receptor Antagonist Inverse agonist 7.6 pKi - 12
pKi 7.6 [12]
D2 receptor Antagonist Antagonist 7.5 pKi - 14
pKi 7.5 [14]
D3 receptor Antagonist Antagonist 7.2 pKi - 14
pKi 7.2 [14]