chlorpromazine

Ligand id: 83

Name: chlorpromazine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 31.78
Molecular weight 318.1
XLogP 4.46
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
5-HT2A receptor Rn Antagonist Inverse agonist 8.7 pKi - 3
pKi 8.7 [3]
5-HT6 receptor Rn Antagonist Inverse agonist 8.4 pKi - 12
pKi 8.4 [12]
H1 receptor Hs Antagonist Antagonist 8.2 pKi - 7
pKi 8.2 [7]
5-HT2A receptor Hs Antagonist Inverse agonist 8.1 pKi - 7
pKi 8.1 [7]
5-HT2C receptor Hs Antagonist Antagonist 7.6 – 8.2 pKi - 5,7
pKi 7.6 – 8.2 [5,7]
D4 receptor Hs Antagonist Antagonist 7.8 pKi - 8
pKi 7.8 [8]
5-HT6 receptor Hs Antagonist Inverse agonist 7.7 – 7.8 pKi - 6,11
pKi 7.7 – 7.8 [6,11]
α2B-adrenoceptor Hs Antagonist Antagonist 7.2 – 8.3 pKi - 1-2
pKi 7.2 – 8.3 [1-2]
5-HT7 receptor Hs Antagonist Inverse agonist 7.6 pKi - 11
pKi 7.6 [11]
5-HT7 receptor Rn Antagonist Inverse agonist 7.6 pKi - 12
pKi 7.6 [12]
D2 receptor Rn Antagonist Antagonist 7.5 pKi - 14
pKi 7.5 [14]
D3 receptor Hs Antagonist Antagonist 7.2 – 7.5 pKi - 4,13
pKi 7.2 – 7.5 [4,13]
D2 receptor Hs Antagonist Antagonist 7.0 – 7.6 pKi - 4,13
pKi 7.0 – 7.6 [4,13]
D3 receptor Rn Antagonist Antagonist 7.2 pKi - 14
pKi 7.2 [14]
α2C-adrenoceptor Hs Antagonist Antagonist 6.9 – 7.4 pKi - 1-2
pKi 6.9 – 7.4 [1-2]
D1 receptor Hs Antagonist Antagonist 7.1 pKi - 15
pKi 7.1 [15]
D5 receptor Hs Antagonist Antagonist 6.9 pKi - 15
pKi 6.9 [15]
α2A-adrenoceptor Hs Antagonist Antagonist 5.9 – 6.6 pKi - 1-2
pKi 5.9 – 6.6 [1-2]
5-HT1A receptor Hs Antagonist Antagonist 6.2 pKi - 9
pKi 6.2 [9]
5-HT7 receptor Mm Antagonist Inverse agonist 5.3 pKi - 10
pKi 5.3 [10]
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
TRPC5 Hs Channel blocker - - - -
Maxi Cl- Hs Activator (extracellular chlorpromazine) - - - -