esuberaprost

Ligand id: 8314

Name: esuberaprost

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 86.99
Molecular weight 398.21
XLogP 3.43
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
The binding affinity (Kd) of beraprost for a single binding site on human platelets is reported in [2] as 133nM, with the affinity of the active enantiomer APS-314d (= esuberaprost) being 100-fold higher, i.e. approximately 13nM.
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
IP receptor Agonist Agonist 7.9 pKd - 2
pKd 7.9 (Kd 1.3x10-8 M) [2]