Ligand id: 8320

Name: ABT-737

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 17
Topological polar surface area 161.81
Molecular weight 812.26
XLogP 11.14
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human other protein targets
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Bcl-2-like 1 Antagonist Antagonist >9.3 pKi - 2
pKi >9.3 (Ki <5x10-10 M) [2]
BCL2, apoptosis regulator Antagonist Antagonist >9.0 pKi - 2
pKi >9.0 (Ki <1x10-9 M) [2]
Bcl-2-like 2 Antagonist Antagonist >9.0 pKi - 2
pKi >9.0 (Ki <1x10-9 M) [2]