Ligand id: 8376

Name: ertugliflozin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 6
Topological polar surface area 108.61
Molecular weight 436.13
XLogP 3.05
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Ertugliflozin is >2200 fold selective for SGLT2 compared to SGLT1 [2].
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Sodium/glucose cotransporter 2 Hs Inhibitor Inhibition 9.1 pIC50 - 2
pIC50 9.1 (IC50 8.77x10-10 M) [2]
Sodium/glucose cotransporter 1 Hs Inhibitor Inhibition 5.7 pIC50 - 2
pIC50 5.7 (IC50 1.96x10-6 M) [2]