AZ628

Ligand id: 8475

Name: AZ628

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 85.23
Molecular weight 451.2
XLogP 4.92
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
In vitro, AZ628 inhibits the activity of the mutant BRAF, BRAFV600E with an IC50 value of 0.6nM [3].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
B-Raf proto-oncogene, serine/threonine kinase Inhibitor Inhibition - - - 1
[1]