AZ20

Ligand id: 8477

Name: AZ20

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 96.56
Molecular weight 412.16
XLogP 2.7
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
In vivo, AZ20 exhibits single agent antiproliferative activity against colorectal adenocarcinoma tumour cell xenografts [1].
Selectivity at enzymes
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Target Sp. Type Action Affinity Units Concentration range (M) Reference
ATR serine/threonine kinase Hs Inhibitor Inhibition 9.3 pIC50 - 1
pIC50 9.3 (IC50 5x10-10 M) [1]
Description: ATR immunoprecipitated from HeLa cells.