niclosamide

Ligand id: 8494

Name: niclosamide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 92.47
Molecular weight 325.99
XLogP 3.7
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Y4 receptor Hs Allosteric modulator Positive - - - 2
[2]
Description: In vitro elevation of agonist-induced accumulation of inositol phosphate to 185% of control.
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
KNa1.1 Hs Activator Agonist 5.5 pEC50 - 1
pEC50 5.5 (EC50 2.9x10-6 M) [1]