tesidolumab   Click here for help

GtoPdb Ligand ID: 8711

Synonyms: LFG-316 | LFG316
Compound class: Antibody
Comment: Tesidolumab is a fully human monoclonal antibody targeting complement C5. Like eculizumab, this investigational monoclonal inhibits terminal complement activation.
Peptide sequence and secondary structural information for this antibody are available from its IMGT/mAb-DB record.
Peptide sequence alignment analysis using the heavy and light variable domains of tesidolumab provide 100% matches to SEQ ID NOs 7 and 8 respectively from patent US8241628 [1]. These peptide sequences correspond to antibody (MOR0)8109 in said patent.
Bioactivity Comments
Tesidolumab binding to C5 protein inhibits the alternative complement pathway as measured by in vitro hemolytic assay and the antibody does not bind C3 or C4 [1].
Selectivity at ligand targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
complement C5 Primary target of this compound Hs Antibody Binding 10.9 – 11.7 pKd - 1
⤷ pKd 10.9 – 11.7 (Kd 1.2x10-11 – 2x10-12 M) [1]
Description: Binding to full length human C5.