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Synonyms: aTyr 1920 | HisRSN4 | HRS(1-60)
Compound class:
Peptide or derivative
Comment: Resokine is a 60 amino acid fragment of the N-terminal of human histidyl-tRNA synthetase (cytoplasmic isoform 1) (HARS; P12081) [1]. HARS belongs to a novel group of naturally occurring proteins termed 'physiocrines' which are extracellular signaling regions of tRNA synthetases reported to modulate immune system pathways. Physiocrines are of interest to the pharmaceutical industry as molecular targets for immunomodulatory therapies (see patents WO2013123432 A2 and US20150093799 A1 for further details [1-2]).
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| Bioactivity Comments |
| Resokine treatment induces an anti-inflammatory signal which blocks the migration of inflammatory cells to the sites of active inflammation in vivo [2]. |
