cephalothin

Ligand id: 8798

Name: cephalothin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 166.55
Molecular weight 396.04
XLogP 0.63
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Cephalothin is reported to inhibit the activity of the human organic anion transporter OAT3 (SLC22A8) [1].
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Organic anion transporter 4 Hs Inhibitor Inhibition 6.7 pKi - 1
pKi 6.7 (Ki 2x10-7 M) [1]
Organic anion transporter 3 Hs Inhibitor Inhibition 7.6 pIC50 - 1
pIC50 7.6 (IC50 2.6x10-8 M) [1]