CGS-27023A

Ligand id: 8846

Name: CGS-27023A

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 117.21
Molecular weight 393.14
XLogP 1.86
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
MMP25 Inhibitor Inhibition 8.8 pIC50 - 2
pIC50 8.8 (IC50 1.5x10-9 M) [2]
MMP9 Inhibitor Inhibition 8.3 pIC50 - 2
pIC50 8.3 (IC50 4.8x10-9 M) [2]
MMP8 Inhibitor Inhibition 8.1 pIC50 - 2
pIC50 8.1 (IC50 7.7x10-9 M) [2]
MMP3 Inhibitor Inhibition 7.8 pIC50 - 2
pIC50 7.8 (IC50 1.6x10-8 M) [2]
MMP14 Inhibitor Inhibition 7.6 pIC50 - 2
pIC50 7.6 (IC50 2.3x10-8 M) [2]
MMP2 Inhibitor Inhibition 7.6 pIC50 - 2
pIC50 7.6 (IC50 2.5x10-8 M) [2]
MMP1 Inhibitor Inhibition 7.3 pIC50 - 2
pIC50 7.3 (IC50 5.6x10-8 M) [2]