CGS-27023A

Ligand id: 8846

Name: CGS-27023A

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 117.21
Molecular weight 393.14
XLogP 1.86
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
MMP25 Hs Inhibitor Inhibition 8.8 pIC50 - 2
pIC50 8.8 (IC50 1.5x10-9 M) [2]
MMP9 Hs Inhibitor Inhibition 8.3 pIC50 - 2
pIC50 8.3 (IC50 4.8x10-9 M) [2]
MMP8 Hs Inhibitor Inhibition 8.1 pIC50 - 2
pIC50 8.1 (IC50 7.7x10-9 M) [2]
MMP3 Hs Inhibitor Inhibition 7.8 pIC50 - 2
pIC50 7.8 (IC50 1.6x10-8 M) [2]
MMP14 Hs Inhibitor Inhibition 7.6 pIC50 - 2
pIC50 7.6 (IC50 2.3x10-8 M) [2]
MMP2 Hs Inhibitor Inhibition 7.6 pIC50 - 2
pIC50 7.6 (IC50 2.5x10-8 M) [2]
MMP1 Hs Inhibitor Inhibition 7.3 pIC50 - 2
pIC50 7.3 (IC50 5.6x10-8 M) [2]