BLU9931

Ligand id: 8862

Name: BLU9931

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 85.37
Molecular weight 508.11
XLogP 4.99
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
BLU9931 is active in vitro and in in vivo HCC xenograft models [1]. The potency of this covalent inhibitor against FRGR4 activity is Kinact/KI = 0.6x105 M-1 min-1 [1].
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
fibroblast growth factor receptor 4 Inhibitor Inhibition 8.5 pIC50 - 1
pIC50 8.5 (IC50 3x10-9 M) [1]
fibroblast growth factor receptor 3 Inhibitor Inhibition 6.8 pIC50 - 1
pIC50 6.8 (IC50 1.5x10-7 M) [1]
fibroblast growth factor receptor 2 Inhibitor Inhibition 6.3 pIC50 - 1
pIC50 6.3 (IC50 4.93x10-7 M) [1]
fibroblast growth factor receptor 1 Inhibitor Inhibition 6.2 pIC50 - 1
pIC50 6.2 (IC50 5.91x10-7 M) [1]