cebranopadol

Ligand id: 8866

Name: cebranopadol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 28.26
Molecular weight 378.21
XLogP 5.96
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
μ receptor Agonist Agonist 9.1 pKi - 2
pKi 9.1 (Ki 7x10-10 M) [2]
Description: Radioligand binding assay
NOP receptor Agonist Agonist 9.1 pKi - 2
pKi 9.1 (Ki 9x10-10 M) [2]
Description: Radioligand binding assay
κ receptor Agonist Agonist 8.6 pKi - 2
pKi 8.6 (Ki 2.6x10-9 M) [2]
Description: Radioligand binding assay
δ receptor Agonist Agonist 7.7 pKi - 2
pKi 7.7 (Ki 1.8x10-8 M) [2]
Description: Radioligand binding assay
NOP receptor Agonist Agonist 7.9 pEC50 - 2
pEC50 7.9 (EC50 1.3x10-8 M) [2]
Description: Stimulation of GTP-γ35S binding
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
NOP receptor Agonist Agonist 9.0 pKi - 2
pKi 9.0 (Ki 1x10-9 M) [2]
Description: Radioligand binding assay
μ receptor Agonist Agonist 8.6 pKi - 2
pKi 8.6 (Ki 2.4x10-9 M) [2]
Description: Radioligand binding assay
κ receptor Agonist Agonist 7.2 pKi - 2
pKi 7.2 (Ki 6.4x10-8 M) [2]
Description: Radioligand binding assay