AC-186

Ligand id: 8897

Name: AC-186

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 20.23
Molecular weight 306.12
XLogP 6.49
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Estrogen receptor-β Agonist Agonist 8.2 pEC50 - 1
pEC50 8.2 (EC50 6x10-9 M) [1]
Description: Measured using Receptor Selection and Amplification Technology (R-SAT).
Estrogen receptor-α Agonist Agonist 5.3 pEC50 - 1
pEC50 5.3 (EC50 5x10-6 M) [1]
Description: Measured using Receptor Selection and Amplification Technology (R-SAT).