CC-223

Ligand id: 8914

Name: CC-223

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 100.47
Molecular weight 397.21
XLogP 1.94
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
CC-223 is selective in a panel screen of other kinases, inhibiting only fms-related tyrosine kinase 4 (FLT4) and colony stimulating factor 1 receptor (c-FMS) with IC50 values below 1μM. It does not inhibit any of the cytochrome p450 enzymes tested, or present a cardiovascular liability with respect to hERG potassium channel inhibition [2].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
mechanistic target of rapamycin kinase Hs Inhibitor Inhibition 8.0 pIC50 - 2
pIC50 8.0 (IC50 1x10-8 M) [2]
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
colony stimulating factor 1 receptor Hs Inhibitor Inhibition 7.6 pIC50 - 2
pIC50 7.6 (IC50 2.8x10-8 M) [2]
fms related tyrosine kinase 4 Hs Inhibitor Inhibition 6.2 pIC50 - 2
pIC50 6.2 (IC50 6.51x10-7 M) [2]