CC-223

Ligand id: 8914

Name: CC-223

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 100.47
Molecular weight 397.21
XLogP 1.94
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
CC-223 is selective in a panel screen of other kinases, inhibiting only fms-related tyrosine kinase 4 (FLT4) and colony stimulating factor 1 receptor (c-FMS) with IC50 values below 1μM. It does not inhibit any of the cytochrome p450 enzymes tested, or present a cardiovascular liability with respect to hERG potassium channel inhibition [2].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
mechanistic target of rapamycin kinase Inhibitor Inhibition 8.0 pIC50 - 2
pIC50 8.0 (IC50 1x10-8 M) [2]
Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
colony stimulating factor 1 receptor Inhibitor Inhibition 7.6 pIC50 - 2
pIC50 7.6 (IC50 2.8x10-8 M) [2]
fms related tyrosine kinase 4 Inhibitor Inhibition 6.2 pIC50 - 2
pIC50 6.2 (IC50 6.51x10-7 M) [2]