AZD8835

Ligand id: 8915

Name: AZD8835

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 11
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 161.97
Molecular weight 469.25
XLogP 0.85
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
AZD8835 dose-dependently inhibits AKT phosphorylation and exhibits 93% tumour growth inhibition in a murine PI3KαH1047R mutated SKOV-3 xenograft tumour model [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Inhibitor Inhibition 8.2 pIC50 - 1
pIC50 8.2 (IC50 5.7x10-9 M) [1]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Inhibitor Inhibition 8.2 pIC50 - 1
pIC50 8.2 (IC50 6.2x10-9 M) [1]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Inhibitor Inhibition 7.1 pIC50 - 1
pIC50 7.1 (IC50 9x10-8 M) [1]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Inhibitor Inhibition 6.4 pIC50 - 1
pIC50 6.4 (IC50 4.31x10-7 M) [1]