Synonyms: REGN-1033 | REGN1033 | SAR-391786 | SAR391786
Compound class:
Antibody
Comment: Trevogrumab is a fully human moncolonal antibody, being investigated for its potential to treat diseases/disorders which are ameliorated or improved by inhibition of myostatin (a.k.a. GDF8).
Peptide sequences and structural information for this antibody are available from its IMGT/mAb-DB record. BLAST peptide searches of patented peptide sequences reveals exact matches between the heavy chain variable region (HCVR) and the light chain variable region (LCVR) of trevogrumab with sequences 360 and 368 respectively, from patent US8840894 B2 [3]. |
Bioactivity Comments |
In rodent studies, trevogrumab treatment increases muscle fiber size, mass, and force production, and prevents experimentally induced muscle mass loss in vivo [1]. The antibody does not bind GDF11 (bone morphogenetic protein 11) or Activin A [1]. |
Selectivity at ligand targets | ||||||||||||||||||||||||||||||||||
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