tezepelumab   Click here for help

GtoPdb Ligand ID: 8933

Synonyms: AMG 157 | AMG-157 | MEDI-9929 | MEDI9929 | tezepelumab-ekko | Tezspire®
Approved drug Immunopharmacology Ligand
tezepelumab is an approved drug (FDA (2021), ENA (2022))
Compound class: Antibody
Comment: Tezepelumab is a fully human IgG2λ monoclonal antibody, that is a potential first-in-class agent that blocks the epithelial-cell-derived cytokine thymic stromal lymphopoietin (TSLP- which is an upstream modulator of multiple inflammatory pathways). It is being investigated for its immunomodulatory action.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
thymic stromal lymphopoietin Primary target of this compound Hs Antibody Binding 10.5 – 10.8 pKd - 3
⤷ pKd 10.5 – 10.8 (Kd 2.92x10-11 – 1.58x10-11 M) [3]