AZD5069

Ligand id: 8948

Name: AZD5069

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 10
Topological polar surface area 158.56
Molecular weight 476.1
XLogP 1.69
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
In a selectivity screening set if 153 human receptors and enzymes, significant levels of activity was only observed at CCR2 (pEC50 5.2) and CCR5 (pEC50 4.9) using ≥10μM AZD5069, in addition to the primary target [3].
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
CXCR2 Antagonist Antagonist 9.1 pIC50 - 3
pIC50 9.1 (IC50 7.9x10-10 M) [3]
Description: Measuring displacement of CXCL8 binding to recombinant CXCR2 in HEK cell membrane preparations.
CXCR1 Antagonist Antagonist 6.9 pIC50 - 3
pIC50 6.9 (IC50 1.25x10-7 M) [3]
Description: Measuring displacement of CXCL8 binding to recombinant CXCR1 in HEK cell membrane preparations.