CUDC-907

Ligand id: 8952

Name: CUDC-907

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 166.96
Molecular weight 508.16
XLogP 0.58
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
CUDC-907 shows greater growth inhibition and proapoptotic activity than single-target PI3K or HDAC inhibitors in vitro and in xenograft models [1].
In addition to the interactions in the table below, CUDC-907 also inhibits HDACs 4, 5, 7, 8 and 9 albeit with lower IC50 values (409, 674, 426, 191, 554nM respectively) [1].
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
histone deacetylase 1 Inhibitor Inhibition 8.8 pIC50 - 1
pIC50 8.8 (IC50 1.7x10-9 M) [1]
histone deacetylase 3 Inhibitor Inhibition 8.7 pIC50 - 1
pIC50 8.7 (IC50 1.8x10-9 M) [1]
histone deacetylase 10 Inhibitor Inhibition 8.6 pIC50 - 1
pIC50 8.6 (IC50 2.8x10-9 M) [1]
histone deacetylase 2 Inhibitor Inhibition 8.3 pIC50 - 1
pIC50 8.3 (IC50 5x10-9 M) [1]
histone deacetylase 11 Inhibitor Inhibition 8.3 pIC50 - 1
pIC50 8.3 (IC50 5.4x10-9 M) [1]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Inhibitor Inhibition 7.7 pIC50 - 1
pIC50 7.7 (IC50 1.9x10-8 M) [1]
histone deacetylase 6 Inhibitor Inhibition 7.6 pIC50 - 1
pIC50 7.6 (IC50 2.7x10-8 M) [1]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Inhibitor Inhibition 7.4 pIC50 - 1
pIC50 7.4 (IC50 3.9x10-8 M) [1]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Inhibitor Inhibition 7.3 pIC50 - 1
pIC50 7.3 (IC50 5.4x10-8 M) [1]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Inhibitor Inhibition 6.5 pIC50 - 1
pIC50 6.5 (IC50 3.11x10-7 M) [1]